Do Parasites Protect Against Alzheimer’s?

 

The Tsimane tribe of Bolivia seem to make a habit of confounding scientists.  First, as reported in a previous blog, they have the healthiest hearts ever – despite living in a constant state of infection-induced inflammation. For years, scientists have been telling us that inflammation is bad for our hearts. Apparently not for the Tsimane.  Now scientists find they experience a much lower rate of Alzheimer’s. Scientists also tell us that those of us who have a copy of the Alzheimer’s gene, ApoE4, have a higher risk of getting Alzheimer’s. Two copies increase the risk by 10%. For us, maybe, but not the Tsimane.

For the Tsimane, the ApoE4 gene seems to be helpful and tribe members rarely have dementia. Dr. Trumble of the Tsimane Project, showed that members of the Tsimane tribe who had either one or two copies of ApoE4, actually performed better on cognitive tests than those that did not have the gene.

Puzzled by this conundrum, Trumble, who knew that most tribe members had suffered from parasitic infections wondered if somehow these infections helped.  The result — for those tribe members who had the ApoE4 gene, but never had an infection, the gene correlated to lower mental fitness.  Studies of ancient bones show that the ApoE4 gene was nearly ubiquitous in our ancestors, and probably helped protect them from parasitic infections. But with no parasites to be found, the gene could be causing the brain to attack itself.  

It seems that our extreme cleanliness habits have led not only to an increase in asthma and allergies, but Alzheimer’s too.

Researchers are hoping that the Tsimane may hold the key to the cure for Alzheimer’s. But they need to be quick – before our industrialized civilization destroys their way of life.

Air Pollution Kills 200,000 Americans Every Year.

          I was listening to Tim Ferris’s podcast with Arnold Schwarzenegger where the Terminator mentioned this stat, saying it was by far the biggest environmental problem we face today and his current mission to help stop it. He wasn’t making these numbers up. Air pollution kills through lung cancer and heart disease. For those that don’t die, air pollution is also responsible for a huge increase in asthma nationwide.
         “Researchers from MIT’s Laboratory for Aviation and the Environment have come out with some sobering new data on air pollution’s impact on Americans’ health.
          The group tracked ground-level emissions from sources such as industrial smokestacks, vehicle tailpipes, marine and rail operations, and commercial and residential heating throughout the United States, and found that such air pollution causes about 200,000 early deaths each year. “
 The smog of pollution over LA.
How deadly is this?
To put this in perspective, during the Civil War 155,000 Americans died per year. During WW2 80,000 Americans died per year. So air pollution kills almost as many Americans per year as WW2 and the Civil war combined.
Worldwide air pollution kills up to seven million people per year, making it one of the biggest killers in the world.

Deconstructing Scientific American’s Anti-Paleo Article

Yesterday science writer Ferris Jabr posted an article on the Scientific American website called How to Really Eat Like a Hunther-Gatherer: Why the Paleo Diet is Half Baked.  Some of his gripes with paleo are accurate, but not unknown to paleo afficiandos and others are simply not well thought out. I’ll go through them here one by one.

 

 

Diet has been an important part of our evolution—as it is for every species—and we have inherited many adaptations from our Paleo predecessors. Understanding how we evolved could, in principle, help us make smarter dietary choices today. But the logic behind the Paleo diet fails in several ways: by making apotheosis of one particular slice of our evolutionary history; by insisting that we are biologically identical to stone age humans; and by denying the benefits of some of our more modern methods of eating.

On his website, Sisson writes that “while the world has changed in innumerable ways in the last 10,000 years (for better and worse), the human genome has changed very little and thus only thrives under similar conditions.” This is simply not true. In fact, this reasoning misconstrues how evolution works. If humans and other organisms could only thrive in circumstances similar to the ones their predecessors lived in, life would not have lasted very long.

 

There is a difference between ‘surviving’ and ‘thriving’. In terms of health and happiness I would not consider the majority of the human race today to be thriving. Obesity is skyrocketing, mental illness is everywhere and even those considered to be of normal psyche’s are far more stressed out than your hunter-gatherer’s – who really do exhibit a remarkable lack of stress and worry.  And while species do need to be able to survive new environments; and while we have evolved slightly since the paleolithic era, our genes have changed no where near as fast as our culture has. If you took a person from 20,000 years ago, gave him a haircut and dressed him in clothes from your local mall he would be indistinguishable from the other shoppers, albeit in better shape. However, that mall and everything inside placed next to a paleolithic village of huts would seem like from another planet. We are simply not adapted to live sedentary lifestyles, indoors and munching on the Western diet.

Even if eating only foods available to hunter–gatherers in the Paleolithic made sense, it would be impossible. As Christina Warinner of the University of Zurich emphasizes in her 2012 TED talk, just about every single species commonly consumed today—whether a fruit, vegetable or animal—is drastically different from its Paleolithic predecessor.

This critique of modern paleo diets is true. Although none of this is new to the paleo community. As Fabr himself writes, people who follow a paleo diet try and mimic the ones of their ancestors as best as we can.

But where Fabr really gets into trouble is when he starts talking about our ancestors and their health. He writes..

 

[ The Paleo Diet ] ignores much of the evidence about our ancestors’ health during their—often brief—individual life spans (even if a minority of our Paleo ancestors made it into their 40s or beyond, many children likely died before age 15

 

Fabr needs to do a little more research into the lifespan of hunter-gatherer’s.  Perhaps he is unaware of this study entitled

Longevity Among Hunter-Gatherers: A Cross-Cultural Examination that found the modal age of death in extant hunter-gatherer tribes to be 72. While it is true that childhood mortality is much higher (which significantly brings down the mean age of death) in these cultures the reason for their early deaths has nothing to do with diet.  It is believed that somewhere between 15%-50% all young babies died from infanticide. Many other’s during childbirth.  Infant mortality in hunter-gatherer tribes was 30 times higher than in modern society and childhood mortality 100 times higher. The reason for these high rates is the natural dangers of living in the wild and living in a world without modern medicine. Ask yourself, would you have made it out of childhood if you had never seen a doctor?  I know that I had a terrible case of pneumonia at age 2, and whose to say without the help of modern medicine that I would have survived.

We can look at the chart of the actual deaths of members of the Hiwi tribe, the tribe that Jabr references and see exactly what it is that killed them.  Most interesting is the data collected from pre-contact times as that would be the most telling of a natural hunter-gatherer tribe. Although it should also be mentioned that the Hiwi have a higher rate of mortality, especially from warfare as in comparison to other extant hunter-gatherer tribes.

Of the 169 total deaths recorded, here is why they died.

Infectious disease (Malaria, respiratory infection, diarrhea, measles)= 70

War (with each other or Venezuelans) = 33

Infanticide=13

Congenital infant death (birth trauma and other childbirth deaths)=12

Environmental Hazard=7

Human Caused Accident=7

Suicide=3

Organic and pathological conditions (heart problems, cancer, liver problems, “swallowed tongue”) = 1

Nutritional deficiencies (starvation or malnourished)=0

Jabr used the Hiwi as an example of anti-paleo but looking at their mortality rate it looks like a glaring win for those who choose to eat a Paleo Diet.  Only one single Hiwi died from a pathological condition(the most common form of death in the US) and considering that “swallowed tongue” was even considered in the category by the researcher’s that could very well have been the reason for that death. While 0 of the Hiwi tribe died from either nutritional deficiencies or starvation. This means that the diet of the Hiwi was certainly not giving them cancer and heart disease. Where does this leave Jabr’s argument? Basically “Lots of Hiwi died from malaria, therefore you should eat pancakes.”

 

recent study in The Lancet looked for signs of atherosclerosis—arteries clogged with cholesterol and fats—in more than one hundred ancient mummies from societies of farmers, foragers and hunter–gatherers around the world, including Egypt, Peru, the southwestern U.S and the Aleutian Islands. “A common assumption is that atherosclerosis is predominately lifestyle-related, and that if modern human beings could emulate preindustrial or even preagricultural lifestyles, that atherosclerosis, or least its clinical manifestations, would be avoided,” the researchers wrote. But they found evidence of probable or definite atherosclerosis in 47 of 137 mummies from each of the different geographical regions.

 

Dr. Stephen Guyanet breaks down this study and what we can draw from these conclusions excellently here. Most importantly he writes that developing atherosclerosis does not equate to having a heart attack. Atherosclerosis may just be something that happens as we age and while it is a risk factor for heart attack, numerous studies of non-industrial cultures have shown them to have atherosclerosis and yet have almost zero incidence of heart attack. It should also be noted that only 6 of the mummies came from a hunter-gatherer culture (what an incredible sample size!) and these hunter-gatherer’s were from the artic, and had to adopt a very extreme diet out of necessity with almost no plant food. In other words, these are not your average hunter-gatherer’s- most of whom lived in more moderate climates.

 

And even if heart disease, cancer, obesity and diabetes were not as common among our predecessors, they still faced numerous threats to their health that modern sanitation and medicine have rendered negligible for people in industrialized nations, such as infestations of parasites and certain lethal bacterial and viral infections.

Actually many of the viruses that humans have fell to over the years came from animals that we were breeding. Hunter-gatherer cultures existed largely without these deadly viruses and hence had no immune system response to them when the white man came and devastated their populations with small pox and other diseases.  Certain hunter-gatherer tribes never even got the common cold. While it is true parasites and bacterial infections were a problem, what does it have to do with modern people eating a diet based on our paleolithic ancestor’s? Absolutely nothing.

 

If we compare the diets of so-called modern hunter-gatherers, however, we see just how difficult it is to find meaningful commonalities and extract useful dietary guidelines from their disparate lives (see infographic). Which hunter–gatherer tribe are we supposed to mimic, exactly? How do we reconcile the Inuit diet—mostly the flesh of sea mammals—with the more varied plant and land animal diet of the Hadza or !Kung? Chucking the many different hunter–gather diets into a blender to come up with some kind of quintessential smoothie is a little ridiculous.

 

Here’s the thing about modern day hunter-gatherer tribes. They have been pushed to the ends of the earth by agriculture societies, and now only exist in the harshest of places. Places where most people have no desire to live. The Hadza and !kung live in sweltering heat of Africa, the Inuit in the freezing cold of the Artic and the Hiwi deep with the jungle of the Amazon where malaria runs amok and all sorts of other things large and small that want to kill you. Yes their diets are extremely different, but that is out of necessity of where they live and what is available to them. The vast majority of our hunter-gatherer ancestors would not have lived in such dramatic conditions and have far more variety and food available to them.

Even as diverse as the diets of the Inuit and the !Kung, they do have some commonalities. Neither of those tribes eats bread, pasta, pizza, cookies, or drink coco-cola. As Jabr himself admits, “The [paleo] diet is largely defined by what they do not do”

 

Meet Grok. According to his online profile, he is a tall, lean, ripped and agile 30-year-old. By every measure, Grok is in superb health: low blood pressure; no inflammation; ideal levels of insulin, glucose, cholesterol and triglycerides. He and his family eat really healthy, too. They gather wild seeds, grasses, and nuts; seasonal vegetables; roots and berries. They hunt and fish their own meat. Between foraging, building sturdy shelters from natural materials, collecting firewood and fending off dangerous predators far larger than himself, Grok’s life is strenuous, perilous and physically demanding. Yet, somehow, he is a stress-free dude who always manages to get enough sleep and finds the time to enjoy moments of tranquility beside gurgling creeks. He is perfectly suited to his environment in every way. He is totally Zen…..

..In contrast to Grok, neither Paleo hunter–gatherers nor our more recent predecessors were sculpted Adonises immune to all disease….Drop Grok into the Hiwi’s midst—or indeed among any modern or ancient hunter–gather society—and he would be a complete aberration. Grok cannot teach us how to live or eat; he never existed

 

Oh really.. Let us check out a few descriptions of hunter-gatherer’s who don’t live in such extreme conditions of the Hiwi. Here is Weston Price’s description of the Torres Straight Islander’s:

It would be difficult to find a more happy and contented people than the primitives in the Torres Straight Islands as they lived without contact with modern civilization.  Indeed, they seem to resent very acutely the modern intrusion. They not only have perfect bodies, but an associated personality and character with a high degree of excellence. One is continually impressed with happiness, peace and health while in their congenial presence (p.187).

 

Or what was said about the people of the Marquesas Islands by the early navigator’s..

The people of the Marquesas Islands were enthusiastically extolled for their beauty and excellence of physical development by the early navigators…They reported the Marquesans as vivacious, happy people…The early navigators were so impressed with the beauty and health of these people that they reported the Marquesas Islands as the Garden of Eden (p.116).

 

While you can find pictures of clearly underfed hunter-gatherer’s living today in extreme conditions of Africa, when we look at pictures of hunter-gatherer’s before they were kicked to the ends of the earth we do find Adonis looking figures. Check out these Australian Aborigines

 

 

Here is another picture…Do you see how well built these guys are? Especially the one on the far left and the far right? This is about as perfect as you can get. And these guys don’t go to the gym or drink protein shakes!

 

 

In case you are thinking it is just the aborigines..it’s not. Here are the Waoroni Indians of Ecuador. Studies on them when they were first discovered showed them to be totally absent of hypertension, heart disease, cancer, anemia, the common cold, polio, pneumonia, small pox, chicken pox, typhus, syphilis, tuberculosis, malaria or serum hepatitis

 

 

Or we can take a look at the Asaro mudmen of Papua New Guinea. Horticulturists who eat similarly to modern day paleo dieter’s. Eating sweet potato’s and fruits from their garden and meat from livestock.

 

Over on twitter, Ferris Jabr proclaimed that he “sees no legitimate reason for prohibiting grains, dairy or legumes”

Well I’m going to give him a few. They aren’t optimally nutritious, and they have immunogenic and allergenic properties in their proteins. They also have higher food palatability and reward which causes you to eat more than you should. Dr. Mattieu Lalonde who got his Ph.D on organic chemistry from Harvard gave a great speach at the Ancestral Health Symposium in 2012 on just why you shouldn’t eat these foods. He is a very smart guy and this is well worth watching. Grains especially don’t come out too well. Legumes fair better and dairy does fine. If you are one of those people who can handle dairy I’m all for it, but many are not. And even Jabr arch-nemesis Mark Sisson says that legumes are ‘ok’. Although people should still be concerned about their phytic acid content, which stops you from absorbing a lot of the nutrients present in legumes. Meaning legumes probably aren’t as nutritious as their content contains. They are also high in lectins which are potentially toxic and can lead to autoimmune problems.

But the answer on grains is clear. If you are looking for the optimal diet, why would you make grains a staple of your diet when they simply aren’t as nutritious as meat and vegetables? Especially grains in their modern form. And the reason they are not as nutritious to our bodies has nothing to do with chance, it is because we did not evolve to eat them over millions of years. These are a relatively new food group to our species. Paleo logic, and it is backed up by nutritional data.

Ferris Jabr says that people like Mark Sisson and other paleo folk don’t understand evolution and science, but I think this post shows that he is the one who has it backwards. After all, Mark Sisson is 60, follows the paleo diet and lifestyle as best he can and has the body of a 20-something UFC fighter.

 

 

Ferris Jabr is a 20-something year old who thinks Mark Sisson’s lifestyle is illogical and has a body similar to Screech.

 

 

The Surprising Correlation Between Cholesterol and Heart Disease – It’s Not What You Think

There is a lot of confusion about cholesterol levels and human health.

Is your Dr. recommended level of total serum cholesterol under 200 justified?

What would the ideal total cholesterol level be for your health? Here is an interesting graph I came across. It measures cholesterol levels and mortality rates from 164 countries around the world. There are some surprising results. It seems that the *ideal* total cholesterol level is higher than what doctors recommend. By ideal I mean it has the smallest correlation to heart disease and overall mortality.

  • Those with a total cholesterol level of 208 were the least likely to die from heart disease. About 220 deaths per 100,000 people.
  • People with a cholesterol level of 150 accounted for 600 deaths from heart disease per 100,000. Meaning those with total cholesterol level of 150 were nearly 3x as likely to die from heart disease than those with cholesterol levels just over 200.
  • Only when cholesterol levels go above 244 do we find that high cholesterol is worse than having a cholesterol level of 150.
  • The ideal cholesterol level to have for not dying of any reason, not just heart disease is 223. But this is largely to a dramatic decrease in infectious and parasitic diseases.
  • My father recently cut down on red meat, and egg yolks and his total cholesterol dropped from 201 to 165. The popular thinking on this is that he just did a great thing for his heart. Yet according to this graph he just doubled his chance of dying from heart disease!

 

Is this result replicated in other studies? Apparently yes. In a study done by the Japanese they found that patients with total cholesterol levels between 200-219 were the least likely to die. The optimal LDL level was considered between 120-139.  A standard lipid profile you get during a routine check up will tell you that having a LDL level of under 130 and a total cholesterol level of under 200 is ideal, but that doesn’t seem to mesh with this data.

According to these results my fathers total cholesterol drop from 201 to 165 increased his risk of mortality by 72%. And his lowering of his LDL from 138 to 101 increased his rate of mortality 20%.

In Conclusion: These are only a few studies, and I am sure there are probably other studies with different results.  But at the very least one has to wonder whether or not the relationship between cholesterol and heart disease is really as scary as people make it out to be. There in fact have been a plethora of books on the subject lately that argue that relationship between cholesterol and heart disease is a myth. I’ll tell you one thing, my total cholesterol level at my last check up was 212, and I’m definitely not worried about. It may even be ideal.